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Disease information Differential genes Enriched regulations/functions/pathways Differential cell type markers Diseases with correlated signatures

Disease information

Disease Name	Alzheimer's Disease
External Links	DO:0080348 DO:0110035 DO:0110037 DO:0110038 DO:0110039 DO:0110041 DO:0110043 DO:0110044 DO:0110045 DO:0110046 DO:0110047 DO:0110048 DO:10652 DO:1443 EFO:0000249 HPO:HP:0002511 ICD10:G30 ICD10:G30.9 ICD10CM:G30 ICD10CM:G30.9 ICD9CM:331.0 MONDO:0004975 MONDO:0007088 MONDO:0007089 MONDO:0011194 MONDO:0011561 MONDO:0011647 MONDO:0011777 MONDO:0012321 MONDO:0012344 MONDO:0012609 MONDO:0012630 MONDO:0012631 MONDO:0012632 MeSH:D000544 NCI:C2866 OMIM:104300
Synonyms	Click to open alzheimer's disease 1 \| alzheimer's disease 2 \| alzheimer's disease 5 \| alzheimer's disease 6 \| alzheimer's disease 7 \| alzheimer's disease 8 \| alzheimer's disease 10 \| alzheimer's disease 11 \| alzheimer's disease 12 \| alzheimer's disease 13 \| alzheimer's disease 14 \| alzheimer's disease 15 \| alzheimer's disease \| cerebral degeneration \| alzheimer disease \| late-onset form of familial alzheimer disease \| alzheimer's disease, unspecified \| alzheimer disease type 1 \| alzheimer disease 2 \| alzheimer disease 5 \| alzheimer disease 6 \| alzheimer disease 7 \| alzheimer disease 8 \| alzheimer disease 10 \| alzheimer disease 11 \| alzheimer disease 12 \| alzheimer disease 13 \| alzheimer disease 14 \| alzheimer disease 15 \| dementia, presenile \| familial alzheimer disease (fad) \| alzheimer disease, late onset \| acute confusional senile dementia \| alzheimer's disease, focal onset \| alzheimer disease, early onset \| alzheimer's dementia \| presenile and senile dementia
Definition	DO: An Alzheimer's disease that has_material_basis_in mutation heterozygous mutation in the APP gene, which encodes the amyloid precursor protein, on chromosome 21q21.
Abbreviation	AD
Organism	Homo sapiens
Tissue Type	Blood
Pathogenic Factor	treatment: compound3
Cell Type	Peripheral blood mononuclear cells (PBMCs)
Control \| Case	GSM3466595	GSM3466569;GSM3466553;GSM3466557;GSM3466561
Data Source	GEO
Accession	GSE122438
Data Type	RNA-Seq
PubMed ID	30559668

Differential genes

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Gene Name	AveExpr Control	AveExpr Case	Log2FC	P-value	Adjusted P-value	Regulation	Boxplot
TLR7	0	90043.892	21.784	0.00e+00	0.00e+00	up
TLR8	0	85981.519	21.144	0.00e+00	0.00e+00	up
VDR	0	80030.261	20.963	0.00e+00	0.00e+00	up
TLR5	0	19769.362	19.639	0.00e+00	0.00e+00	up
MGAT3	0	14567.006	18.349	0.00e+00	0.00e+00	up
CD40	444.401	107519.695	11.29	0.00e+00	0.00e+00	up
NFKBIA	204347.807	329061.159	7.052	0.00e+00	0.00e+00	up
CXCL8	73358.997	54907.368	5.1	0.00e+00	0.00e+00	up
FOS	65674.197	33642.129	3.601	0.00e+00	0.00e+00	up
SOD2	35491.255	4896.27	1.377	0.00e+00	0.00e+00	up

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Enriched regulations/functions/pathways

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GO KEGG GSEA

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TF	Regulation	Gene Ratio	Bg Ratio	P-value	Adjusted P-value	Enriched Gene	Enriched Gene	Count
STAT6	up	4/8	36/2470	0.00e+00	0.00e+00	CD40 CXCL8 TLR4 FOS		4
RELA	down	7/7	300/2470	0.00e+00	0.00e+00	CCL2 IL1B IL1RN TP53 IRF1 TNFAIP3 EGR1		7
NFKB1	down	7/7	303/2470	0.00e+00	0.00e+00	CCL2 IL1B IL1RN TP53 IRF1 TNFAIP3 EGR1		7
REL	down	3/7	22/2470	0.00e+00	1.00e-03	CCL2 IL1B TNFAIP3		3
STAT1	down	4/7	84/2470	0.00e+00	1.00e-03	CCL2 IL1B TP53 IRF1		4
STAT3	down	4/7	139/2470	0.00e+00	5.00e-03	CCL2 IL1RN TP53 IRF1		4
STAT2	down	2/7	11/2470	0.00e+00	5.00e-03	CCL2 IRF1		2
RELA	up	5/8	300/2470	1.00e-03	2.30e-02	TLR7 CD40 NFKBIA CXCL8 SOD2		5
NFE2L2	up	2/8	16/2470	1.00e-03	2.30e-02	CXCL8 SOD2		2
NFKB1	up	5/8	303/2470	1.00e-03	2.30e-02	TLR7 CD40 NFKBIA CXCL8 SOD2		5

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Differential cell type markers

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Cell Type	Source	Regulation	Gene Ratio	Bg Ratio	Hypergeometric P-value	Adjusted P-value	Marker Gene	Marker Gene
Leukocyte:Undefined	CellMarker	up	2/10	10/12662	0.00e+00	1.00e-03	CD40 TLR4
Neutrophil:Kidney	CellMarker	up	3/10	80/12662	0.00e+00	1.00e-03	CXCL8 FOS SOD2
Paneth cell:Large intestine	CellMarker	up	4/10	311/12662	0.00e+00	2.00e-03	CD40 CXCL8 TLR4 SOD2
Satellite glial cells:Brain	PanglaoDB	up	2/10	24/12662	0.00e+00	3.00e-03	CXCL8 TLR4
Astrocyte:Brain	CellMarker	up	3/10	166/12662	0.00e+00	4.00e-03	CD40 NFKBIA FOS
Macrophage:Undefined	CellMarker	up	2/10	35/12662	0.00e+00	4.00e-03	CD40 TLR4
Microglial cell:Embryonic prefrontal cortex	CellMarker	up	4/10	474/12662	0.00e+00	4.00e-03	TLR7 NFKBIA TLR4 FOS
Macrophage:Lung	CellMarker	down	2/7	18/12662	0.00e+00	2.00e-03	CCL2 IL1RN
CD1C+	CellMarker	down	2/7	54/12662	0.00e+00	6.00e-03	IL1B IL1RN
Paneth cell:Large intestine	CellMarker	down	3/7	311/12662	0.00e+00	6.00e-03	IL1B IL1RN TNFAIP3

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Diseases with correlated signatures

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DSAID	Disease	Enrichment Score	P-value	Organism	+/-	Analysis
DSA02284	Systemic Lupus Erythematosus	677	0.00e+00	Homo sapiens	+
DSA00276	Parkinson's Disease	429.635	0.00e+00	Homo sapiens	-
DSA07315	Multiple Sclerosis	429.635	0.00e+00	Homo sapiens	-
DSA00804	Acute Liver Inflammation	418.894	0.00e+00	Homo sapiens	-
DSA02011	Acute Myeloid Leukemia (Aml-M2)	290.143	0.00e+00	Homo sapiens	+
DSA04438	Primary Progressive Multiple Sclerosis	279.262	0.00e+00	Homo sapiens	-
DSA00805	Acute Liver Inflammation	265.964	0.00e+00	Homo sapiens	-
DSA03805	Type 1 Diabetes	253.875	0.00e+00	Homo sapiens	+
DSA08148	Influenza	232.719	0.00e+00	Homo sapiens	-
DSA09830	Rheumatoid Arthritis	223.41	0.00e+00	Homo sapiens	+

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