Detail

Basic Information

GTO ID GTD0009
Accession GSE229785
Altered gene miR-28
Gene xrefs Gene ID: 407020
Gene symbol: MIR28
Ensembl ID: ENSG00000207651
Treatment miR-28 mimics
Control GSM7177654;GSM7177655
Case GSM7177644;GSM7177645
Disease Diffuse Large B Cell Lymphoma
Disease information Disease group: Cancer
Definition: A B-cell lymphoma that is a cancer of B cells presenting as an aggressive tumour which can arise in virtually any part of the body.
Xref: DO:0050745 | EFO:0000403 | EFO:0001642 | EFO:1000157 | EFO:1000490 | ICD10:C83.3 | MONDO:0002571 | MONDO:0018905 | MSH:D016403 | NCI:C8851 | ORDO:544
Organism Homo sapiens
Tissue/Cell type Diffuse large B cell lymphoma tumor cell line
Characteristics time of ibrutinib treatment: 20h
Strategy RNA-seq
Platform GPL20301
Vector information
Vectorlentivirus
Vector Typelentiviral vector
Transgene Inserted Genethe miR-28 precursor sequence
Vector Production MethodThe miR-28 precursor sequence was cloned into the doxycycline-inducible pTRIPZ vector (Thermo scientific). Lentiviral supernatants were obtained 48 h after transfection of 293 T cells with packaging vectors (VSVG, Δ9.8) and pTRIPZ plasmids.

Differential genes

Gene Name AveExpr Control AveExpr Case Log2FC P-value Adjusted P-value Regulation Boxplot

Volcano plot

Heatmap

Enriched regulations/functions/pathways


TF Regulation Gene Ratio Bg Ratio P-value Adjusted P-value Enriched Gene Count

ID Terms Size ES NES P-value Adjusted P-value Plot


Differential cell type markers

Cell Type Source Regulation Gene Ratio Bg Ratio Hypergeometric P-value Adjusted P-value Marker Gene