Single-cell overall analysis Basic information Differential genes Enriched regulations/functions/pathways Differential cell type markers
Single-cell cluster analysis Cell clustering Marker genes Differential genes in clusters

Single-cell overall analysis

Detail

Basic Information

GTO ID GTD0006
Accession GSE153099
Altered gene CRX
Gene xrefs Gene ID: 1406
Gene symbol: CRX
Ensembl ID: ENSG00000105392
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Treatment AAV-mediated CRX
Control GSM4634067;GSM4634068
Case GSM4634065;GSM4634066
Disease Leber Congenital Amaurosis
Disease information Disease group: Genetic Disease
Definition: A retinal disease that is characterized by nystagmus, sluggish or no pupillary responses, and severe vision loss or blindness.
Xref: DO:14791 | MONDO:0018998 | MSH:D057130 | NCI:C129075 | ORDO:65
Organism Homo sapiens
Tissue/Cell type Retinal Organoid
Strategy scRNA-seq
Platform GPL24676
Vector information
Vectoradeno-associated virus
Vector Typeadeno-associated virus serotype 9 (AAV9) vector
Transgene Inserted Genecorrect human CRX transgene
Regulatory Elementa human CRX promoter

Differential genes

Gene Name Log2FC Pct_Control Pct_Case P-value Adjusted P-value Regulation Boxplot

Volcano plot

Enriched regulations/functions/pathways


TF Regulation Gene Ratio Bg Ratio P-value Adjusted P-value Enriched Gene Count

ID Terms Size ES NES P-value Adjusted P-value Plot


Differential cell type markers

Cell Type Source Regulation Gene Ratio Bg Ratio Hypergeometric P-value Adjusted P-value Marker Gene

Single-cell cluster analysis

Cell clustering

Cell ratio

Marker genes

Gene Name Log2FC Pct_Control Pct_Case P-value Adjusted P-value Cluster Violin plot

Differential genes in clusters

Gene Name Log2FC Pct_Control Pct_Case P-value Adjusted P-value Cluster Boxplot