Single-cell overall analysis Basic information Differential genes Enriched regulations/functions/pathways Differential cell type markers
Single-cell cluster analysis Cell clustering Marker genes Differential genes in clusters

Single-cell overall analysis

Detail

Basic Information

GTO ID GTD0075
Accession GSE164551
Gene therapy-related clinical trial GTC1583
Altered gene BCMA
Gene xrefs Gene ID: 608
Gene symbol: TNFRSF17
Ensembl ID: ENSG00000048462
Treatment BCMA CAR-T cell
Control GSM5013821
Case GSM5013825
Disease Multiple Myeloma
Disease information Disease group: Cancer
Definition: A myeloid neoplasm that is located_in the plasma cells in bone marrow.
Xref: DO:9538 | EFO:0001378 | HPO:HP:0006775 | ICD10:C90.0 | MONDO:0009693 | MSH:D009101 | NCI:C3242 | OMIM:254500 | ORDO:29073
Organism Homo sapiens
Tissue/Cell type Bone Marrow
Characteristics 8 months after first infusion
Strategy scRNA-seq
Platform GPL20795

Differential genes

Volcano plot

−3−2−101234501020304050
Up(7199)Down(5507)Not Sig(4)Log2FC-Log10(adjusted P-value)001.3

Enriched regulations/functions/pathways




203040506070ribonucleoprotein complex biogenesisregulation of apoptotic signaling pathwayviral processregulation of T cell activationleukocyte cell-cell adhesionactivation of immune responsemyeloid cell differentiationregulation of intrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathwaycytoplasmic translation
-Log10(P-value)

Differential cell type markers


Single-cell cluster analysis

Cell ratio

Classical MonocytesErythroid-like and erythroid precursor cellsNaive B cellsNaive CD4+ T cellsNaive CD8+ T cellsNatural killer cellsPlasma B cellsPlasmacytoid Dendritic cellsProgenitor cellsUnknown00.20.40.60.81
CaseControlClusterRatio

Marker genes

Differential genes in clusters