Basic Information



GTO ID GTC4013
Trial ID NCT02636036
Disease Colorectal Cancer | Head and Neck Squamous Cell Carcinoma
Altered gene E1A|E1B
Therapeutic/Target gene Therapeutic gene
TherapyDNA oncolytic virus
Treatment ColoAd1|Enadenotucirev
Co-treatment Nivolumab/Ipilimumab
PhasePhase1
Recruitment statusCompleted
TitleA Phase I Multicenter, Open Label Study of Enadenotucirev Combined With PD-1 Inhibitor in Subjects With Metastatic or Advanced Epithelial Tumors
Year2016
CountryUnited States
Company sponsorAkamis Bio
Other ID(s)ColoAd1-1003
Vector information
Vectoradenovirus
ConstructB Ad11p/Ad3 chimeric adenovirus
Vector typenovel group B Ad11p/Ad3 chimeric adenovirus
Transgene/Inserted geneAd11p; Ad3

Clinical Result

Cohort 1
Administration route None
Pts 51
Age Adult, Older_Adult
References PMID: 37094988

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