Basic Information

Gene symbol CXCL10 Synonyms C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1 Type of gene protein-coding
Description C-X-C motif chemokine ligand 10

Gene symbol CXCL9 Synonyms CMK, Humig, MIG, SCYB9, crg-10 Type of gene protein-coding
Description C-X-C motif chemokine ligand 9



Gene symbol FAP Synonyms DPPIV, FAPA, FAPalpha, SIMP Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description fibroblast activation protein alpha

Gene symbol IFNA2 Synonyms IFN-alpha-2, IFN-alphaA, IFNA, IFNA2B, leIF A Type of gene protein-coding
Description interferon alpha 2

GTO ID GTC4007
Trial ID NCT04830592
Disease Head and Neck Squamous Cell Carcinoma
Altered gene E1A|E1B|FAP|CXCL9|CXCL10|IFNA2
Therapeutic/Target gene Therapeutic gene
TherapyDNA oncolytic virus
Treatment NG-641
PhasePhase1
Recruitment statusActive, Not Recruiting
TitleA Multicentre, Open-label, Dose-escalating, Phase Ib, Study of Intravenous Dosing of NG-641, as Monotherapy or in Combination With Pembrolizumab in Patients With Surgically Resectable Squamous Cell Carcinoma of the Head and Neck
Year2021
CountryUnited Kingdom
Company sponsorAkamis Bio
Other ID(s)NG-641-02
Vector information
Vectoradenovirus
Transgene/Inserted genebispecific human fibroblast activation protein; human CD3 epsilon bispecific T cell activator antibody; CXC motif chemokine ligands (CXCL) 9 and 10, and interferon α2
Additional featureFAP/CD3, CXCL9, CXCL10, IFNa

Clinical Result

Cohort1: NG-641
Administration route intravenous infusion
Age Adult, Older_Adult
References PMID: 36897458
Cohort2: NG-641_Pembrolizumab
Administration route intravenous infusion
Age Adult, Older_Adult
References PMID: 36897458

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