Basic Information


Gene symbol IL2 Synonyms IL-2, TCGF, lymphokine Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description interleukin 2

Gene symbol TNF Synonyms DIF, TNF-alpha, TNFA, TNFSF2, TNLG1F Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description tumor necrosis factor

GTO ID GTC4006
Trial ID NCT04695327
Disease Solid Tumor
Altered gene E1A|TNFa|IL-2
Therapeutic/Target gene Therapeutic gene
TherapyDNA oncolytic virus
Treatment TILT-123|igrelimogene litadenorepvec
PhasePhase1
Recruitment statusRecruiting
TitleA Phase 1, Open-Label, Dose-escalation Clinical Trial of Tumor Necrosis Factor Alpha and Interleukin-2 Coding Oncolytic Adenovirus (TILT-123) in Patients With Injectable Solid Tumors
Year2021
CountryFinland
Company sponsorTILT Biotherapeutics Ltd.
Other ID(s)TILT-T115|2020-001778-31
Vector information
Vectoradenovirus
ConstructAd5/3-delta24-TNFα-IRES-IL2
Vector typeserotype 5 based adenovirus
Transgene/Inserted geneTNFa; IL2
Regulatory elementan E2F promoter
Viral genome modificationTILT-123 is based on a serotype 5 adenovirus, with a 24 kb deletion in the E1A region and addition of the E2F promoter to facilitate cancer cell-specific replication. The fiber knob of the virus has been changed to a serotype 3 knob to enhance systemic delivery and cancer cell entry. TILT-123 carries two immunostimulatory transgenes: TNFα and IL2.
Additional featureTNFα-IRES-IL2 in E3

Clinical Result

Cohort 1
Administration route intratumoral infusion
Pts 18
Age Adult, Older_Adult
References PMID: 38546220

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