| Vector | adenovirus |
| Construct | Ad5/3-delta24-GMCSF |
| Vector type | serotype 5 adenovirus |
| Transgene/Inserted gene | GM-CSF, which enhances antitumor immunity by recruiting antigen-presenting cells (APCs) and natural killer (NK) cells, activates and matures APCs at the tumor site, thereby potentiating the ability of ONCOS-102 to induce cellular immunity against the tumor in which it replicates. |
| Viral genome modification | ONCOS-102 has a genetically modified fiber with a serotype 3 knob for enhanced gene delivery to cancer cells. A 24-bp deletion has been made in the Rb binding site of the E1A gene. |
| Additional feature | GM-CSF |
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