Basic Information


Gene symbol TNFSF9 Synonyms 4-1BB-L, CD137L, TNLG5A Type of gene protein-coding
Description TNF superfamily member 9

GTO ID GTC3999
Trial ID NCT04714983
Disease Colorectal Cancer | Breast Cancer | Melanoma
Altered gene E1A|TNFSF9
Therapeutic/Target gene Therapeutic gene
TherapyDNA oncolytic virus
Treatment DNX-2440
PhasePhase1
Recruitment statusSuspended
TitleA Phase I Safety and Window-of-opportunity Study of Preoperative Intratumoral Injection of OX40-ligand Expressing Oncolytic Adenovirus (DNX-2440) in Patients With Resectable Liver Metastasis
Year2021
CountryUnited States
Company sponsorDNAtrix, Inc.
Other ID(s)2440LM-002
Vector information
Vectoradenovirus
ConstructAd5-delta24-RGD-OX40L
Vector typeadenoviral serotype 5 (Ad5) vector
Transgene/Inserted geneOX40L
Additional featureCMV-OX40L-BGHpA repl. E3

Clinical Result

Cohort 1
Administration route intratumoral injection
Pts 30
Age Adult, Older_Adult

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