Basic Information



GTO ID GTC3996
Trial ID NCT03178032
Disease Brain Glioma
Altered gene E1A|RGD
Therapeutic/Target gene Therapeutic gene
TherapyDNA oncolytic virus
Treatment Ad5-Delta 24RGD|DNX-2401|tasadenoturev
PhasePhase1
Recruitment statusCompleted
TitlePhase I Trial of DNX-2401 for Diffuse Intrinsic Pontine Glioma Newly Diagnosed in Pediatric Patients.
Year2017
CountrySpain
Company sponsorClinica Universidad de Navarra, Universidad de Navarra
Other ID(s)D24-DIPG
Vector information
Vectoradenovirus
ConstructAd5-Delta 24RGD
Vector typetumor-selective, replication-competent oncolytic adenovirus
Transgene/Inserted geneRGD-motif, which was engineered into the fiber H-loop, enabling the virus to use αvβ3 or αvβ5 integrins to enter cells.
Regulatory elementRGD-motif
Viral genome modification24-base-pair deletion in the E1A gene

Clinical Result

Cohort 1
Administration route intratumoral infusion
Pts 12
Age Child, Adult
References PMID: 31138805

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