Basic Information



GTO ID GTC3994
Trial ID NCT02798406
Disease Brain Glioma
Altered gene E1A|RGD
Therapeutic/Target gene Therapeutic gene
TherapyDNA oncolytic virus
Treatment Ad5-Delta 24RGD|DNX-2401|tasadenoturev
Co-treatment pembrolizumab
PhasePhase2
Recruitment statusCompleted
TitleA Phase II, Multi-center, Open-label Study of a Conditionally Replicative Adenovirus (DNX-2401) With Pembrolizumab (KEYTRUDA®) for Recurrent Glioblastoma or Gliosarcoma (CAPTIVE/KEYNOTE-192)
Year2016
CountryUnited States|Canada
Company sponsorDNAtrix, Inc.
Other ID(s)2401BT-002P
Vector information
Vectoradenovirus
ConstructAd5-Delta 24RGD
Vector typetumor-selective, replication-competent oncolytic adenovirus
Transgene/Inserted geneRGD-motif, which was engineered into the fiber H-loop, enabling the virus to use αvβ3 or αvβ5 integrins to enter cells.
Regulatory elementRGD-motif
Viral genome modification24-base-pair deletion in the E1A gene

Clinical Result

Cohort1: dose level 1
Administration route intratumoral injection
Dosage DNX-2401, 5e8 vp|pembrolizumab, Q3W
Age Adult, Older_Adult
References PMID: 37188783
Cohort2: dose level 2
Administration route intratumoral injection
Dosage DNX-2401, 5e9 vp|pembrolizumab, Q3W
Age Adult, Older_Adult
References PMID: 37188783
Cohort3: dose level 3
Administration route intratumoral injection
Dosage DNX-2401, 5e10 vp|pembrolizumab, Q3W
Age Adult, Older_Adult
References PMID: 37188783

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