Detail

Basic Information Clinical Results Relationship Graph

Basic Information

Gene symbol	E2F1	Synonyms	E2F-1, RBAP1, RBBP3, RBP3	Type of gene	protein-coding
Chromosome	20	Map location	20q11.22	dbXrefs
Gene perturbation-related omics dataset	PerturbAtlas \| PertOrg
Description	E2F transcription factor 1

Gene symbol	SPAM1	Synonyms	HEL-S-96n, HYA1, HYAL1, HYAL3, HYAL5, PH-20, PH20, SPAG15	Type of gene	protein-coding
Chromosome	7	Map location	7q31.32	dbXrefs
Description	sperm adhesion molecule 1

GTO ID	GTC3984
Trial ID	NCT03284268
Disease	Retinoblastoma
Altered gene	E2F1\|PH20
Therapeutic/Target gene	Therapeutic gene
Therapy	DNA oncolytic virus
Treatment	VCN-01
Phase	Not Applicable
Recruitment status	Completed
Title	Phase I Study, Single Site, Open Label With Dose Escalation, for Evaluate Safety and the Oncolitic Adenovirus VCN-01 Activity in Patients With Refractory Retinoblastoma
Year	2017
Country	Spain
Company sponsor	Fundació Sant Joan de Déu
Other ID(s)	FSJD-RTB-2015

Vector information

Vector	adenovirus
Construct	Ad5-E2F-delta24-RGD -PH20
Vector type	oncolytic adenovirus (Ad5 based)
Transgene/Inserted gene	Hyaluronidase (PH20), which enables the virus to degrade the extracellular matrix, disrupt the tumor stroma, thus enhancing the intratumoral spreading of the virus.
Viral genome modification	VCN-01 incorporates an RGKD integrin motif in the fiber shaft, an effective method for liver detargeting and tumor retargeting.
Additional feature	Hyaluronidase (PH20)

Clinical Result

Cohort1: dose level 1

Administration route	intravitreal injection
Dosage	2E9 viral particules/eye
Age	Child

Cohort2: dose level 2

Administration route	intravitreal injection
Dosage	2E10 viral particules/eye
Age	Child

Cohort3: dose level 3

Administration route	intravitreal injection
Dosage	2E11 viral particules/eye
Age	Child

Relationship Graph

Overview of Knowledge Graph