Basic Information

Gene symbol E2F1 Synonyms E2F-1, RBAP1, RBBP3, RBP3 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description E2F transcription factor 1

Gene symbol SPAM1 Synonyms HEL-S-96n, HYA1, HYAL1, HYAL3, HYAL5, PH-20, PH20, SPAG15 Type of gene protein-coding
Description sperm adhesion molecule 1

GTO ID GTC3982
Trial ID NCT02045602
Disease Solid Tumor | Pancreatic Adenocarcinoma
Altered gene E2F1|PH20
Therapeutic/Target gene Therapeutic gene
TherapyDNA oncolytic virus
Treatment VCN-01
PhasePhase1
Recruitment statusCompleted
TitleA Phase I, Multicenter, Open-label, Dose Escalation Study of Intravenous Administration of VCN-01 Oncolytic Adenovirus With or Without Gemcitabine and Abraxane® in Patients With Advanced Solid Tumors
Year2014
CountrySpain
Company sponsorTheriva Biologics SL
Other ID(s)P-VCNA-001|2012-005555-16
Vector information
Vectoradenovirus
ConstructAd5-E2F-delta24-RGD -PH20
Vector typeoncolytic adenovirus (Ad5 based)
Transgene/Inserted geneHyaluronidase (PH20), which enables the virus to degrade the extracellular matrix, disrupt the tumor stroma, thus enhancing the intratumoral spreading of the virus.
Viral genome modificationVCN-01 incorporates an RGKD integrin motif in the fiber shaft, an effective method for liver detargeting and tumor retargeting.
Additional featureHyaluronidase (PH20)

Clinical Result

Cohort1: VCN-01
Administration route intravenous injection
Age Adult, Older_Adult
References PMID: 35338084
Cohort2: VCN-01_Gemcitabine_Abraxane
Administration route intravenous injection
Age Adult, Older_Adult
References PMID: 35338084

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