Basic Information

Gene symbol MIR122 Synonyms MIR122A, MIRN122, MIRN122A, hsa-mir-122, miRNA122, miRNA122A, mir-122 Type of gene ncRNA
Gene perturbation-related omics dataset PertOrg
Description microRNA 122

GTO ID GTC3977
Trial ID NCT02749331
Disease Neuroendocrine Tumor
Altered gene miR122
Therapeutic/Target gene Therapeutic gene
TherapyDNA oncolytic virus
Treatment AdVince|Ad5PeptideTransductionDomain(PTD)(CgA-E1AmiR122)
PhasePhase1|Phase2
Recruitment statusUnknown
TitleStudy of Recombinant Adenovirus (AdVince) in Patients With Neuroendocrine Tumors; Safety and Efficacy
Year2016
CountrySweden
Company sponsorUppsala University
Other ID(s)VIRUSNET201401|2014-000614-64
Vector information
Vectoradenovirus
ConstructCgA -PTD-miR122
Transgene/Inserted genemiR-122 target sequences for reduced liver toxicity
Regulatory elementhuman chromogranin A gene promoter
Additional featurePTD-peptide, miRNA 122

Clinical Result

Cohort1: dose level 1
Administration route intrahepatic artery infusion
Dosage 1E10 virus particles
Age Adult, Older_Adult
Cohort2: dose level 2
Administration route intrahepatic artery infusion
Dosage 1E11 virus particles
Age Adult, Older_Adult
Cohort3: dose level 3
Administration route intrahepatic artery infusion
Dosage 3E11 virus particles
Age Adult, Older_Adult
Cohort4: dose level 4
Administration route intrahepatic artery infusion
Dosage 1E12 virus particles
Age Adult, Older_Adult

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