Basic Information



Gene symbol TERT Synonyms CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description telomerase reverse transcriptase

GTO ID GTC3975
Trial ID NCT04391049
Disease Squamous Cell Carcinoma
Altered gene E1A|E1B|TERT
Therapeutic/Target gene Therapeutic gene
TherapyDNA oncolytic virus
Treatment Telomelysin|OBP-301
Co-treatment carboplatin|paclitaxel|radiation
PhasePhase1
Recruitment statusActive, Not Recruiting
TitlePhase I Trial With Expansion Cohort of OBP-301 (Telomelysin™) and Definitive Chemoradiation for Patients With Locally Advanced Esophageal and Gastroesophageal Cancer Who Are Not Candidates for Surgery
Year2021
CountryUnited States
Company sponsorNRG Oncology
Other ID(s)NRG-GI007|NCI-2020-02320|NRG-GI007|NRG-GI007|U10CA180868
Vector information
Vectoradenovirus
ConstructAd5-hTERT-E1A-IRES-E1B
Vector typea first generation, replication-defective adenovirus serotype 5 (Ad5) vector
Transgene/Inserted genehTERT, which can be utilized as a molecular switch for the selective expression of target genes in tumor cells.
Regulatory elementa human telomerase reverse transcriptase gene (hTERT) promoter

Clinical Result

Cohort 1
Administration route intratumoral injection|intravenous infusion
Dosage OBP-301, on days -3, 12, and 26|carboplatin, on days 1, 8, 15, 22, and 29|paclitaxel, on days 1, 8, 15, 22, and 29
Pts 16
Age Adult, Older_Adult

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