Basic Information



Gene symbol TERT Synonyms CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description telomerase reverse transcriptase

GTO ID GTC3973
Trial ID NCT03921021
Disease Esophagogastric Adenocarcinoma
Altered gene E1A|E1B|TERT
Therapeutic/Target gene Therapeutic gene
TherapyDNA oncolytic virus
Treatment Telomelysin|OBP-301
Co-treatment pembrolizumab
PhasePhase2
Recruitment statusCompleted
TitlePhase 2 Study of Telomelysin (OBP-301) in Combination With Pembrolizumab in Esophagogastric Adenocarcinoma
Year2019
CountryUnited States
Company sponsorWeill Medical College of Cornell University
Other ID(s)1807019403
Vector information
Vectoradenovirus
ConstructAd5-hTERT-E1A-IRES-E1B
Vector typea first generation, replication-defective adenovirus serotype 5 (Ad5) vector
Transgene/Inserted genehTERT, which can be utilized as a molecular switch for the selective expression of target genes in tumor cells.
Regulatory elementa human telomerase reverse transcriptase gene (hTERT) promoter

Clinical Result

Cohort 1
Administration route intratumoral injection
Dosage Telomelysin, 2E12 viral particles (VP), every two weeks x 4 injections|pembrolizumab, 200 mg, every 3 weeks
Pts 17
Age Adult, Older_Adult
Adverse reactions 13/17(All-cause mortality); 15/17(Blood and lymphatic system disorders; Cardiac disorders; Gastrointestinal disorders; General disorders; Infections and infestations; Metabolism and nutrition disorders; Musculoskeletal and connective tissue disorders; Psychiatric disorders; Respiratory, thoracic and mediastinal disorders)

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