Basic Information



Gene symbol TERT Synonyms CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description telomerase reverse transcriptase

GTO ID GTC3971
Trial ID NCT03172819
Disease Advanced Solid Tumor
Altered gene E1A|E1B|TERT
Therapeutic/Target gene Therapeutic gene
TherapyDNA oncolytic virus
Treatment Telomelysin|OBP-301
Co-treatment Pembrolizumab
PhasePhase1
Recruitment statusCompleted
TitleAn Open Label Phase I Study to Evaluate the Safety and Efficacy of OBP-301 With Pembrolizumab in Patients With Advanced Solid Tumors
Year2017
CountryJapan
Company sponsorToshihiko Doi
Other ID(s)EPOC1505
Vector information
Vectoradenovirus
ConstructAd5-hTERT-E1A-IRES-E1B
Vector typea first generation, replication-defective adenovirus serotype 5 (Ad5) vector
Transgene/Inserted genehTERT, which can be utilized as a molecular switch for the selective expression of target genes in tumor cells.
Regulatory elementa human telomerase reverse transcriptase gene (hTERT) promoter

Clinical Result

Cohort 1
Administration route intratumoral injection|intravenous infusion
Dosage OBP-301, at Day 1, Day 15, and Day 29|Pembrolizumab, 200 mg, at Day 8, continue every 3 weeks until discontinuation
Pts 22
Age Adult, Older_Adult

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