Basic Information



Gene symbol TERT Synonyms CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description telomerase reverse transcriptase

GTO ID GTC3969
Trial ID NCT02293850
Disease Hepatocellular Carcinoma
Altered gene E1A|E1B|TERT
Therapeutic/Target gene Therapeutic gene
TherapyDNA oncolytic virus
Treatment Telomelysin|OBP-301
PhasePhase1
Recruitment statusUnknown
TitleA Phase I Study to Evaluate the Safety and Efficacy of Telomelysin (OBP-301) in Patients With Hepatocellular Carcinoma
Year2014
CountryKorea,Republic of|Taiwan
Company sponsorOncolys BioPharma Inc
Other ID(s)CT-OT-21
Vector information
Vectoradenovirus
ConstructAd5-hTERT-E1A-IRES-E1B
Vector typea first generation, replication-defective adenovirus serotype 5 (Ad5) vector
Transgene/Inserted genehTERT, which can be utilized as a molecular switch for the selective expression of target genes in tumor cells.
Regulatory elementa human telomerase reverse transcriptase gene (hTERT) promoter
Vector production methodOBP-301 was prepared at Introgen Therapeutics (Houston, TX) and maintained in a buffer (20 mM Tris [pH 8.0]) using aseptic techniques in a biocontainment level 2 ISO class 5 biosafety cabinet. The concentration was 1 × 1012 VPs per mL, and a 2 mL recoverable volume was added to 5 mL glass vials. OBP-301 was stored at −60°C or lower.

Clinical Result

Cohort1: dose level 1
Administration route intratumoral injection
Dosage 1E10 viral particle (VP)/ tumor
Age Adult, Older_Adult
References PMID: 37060176
Cohort2: dose level 2
Administration route intratumoral injection
Dosage 1E11 viral particle (VP)/ tumor
Age Adult, Older_Adult
References PMID: 37060176
Cohort3: dose level 3
Administration route intratumoral injection
Dosage 1E12 viral particle (VP)/ tumor
Age Adult, Older_Adult
References PMID: 37060176

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