Basic Information

Gene symbol CSF2 Synonyms CSF, GMCSF Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description colony stimulating factor 2

Gene symbol E2F1 Synonyms E2F-1, RBAP1, RBBP3, RBP3 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description E2F transcription factor 1

GTO ID GTC3968
Trial ID NCT04387461
Disease Bladder Cancer
Altered gene E2F1|CSF2
Therapeutic/Target gene Therapeutic gene
TherapyDNA oncolytic virus
Treatment CG0070|Cretostimogene Grenadenorepvec
Co-treatment Pembrolizumab
PhasePhase2
Recruitment statusUnknown
TitleA Phase 2, Single Arm Study of CG0070 Combined With Pembrolizumab in Patients With Non Muscle Invasive Bladder Cancer (NMIBC) Unresponsive to Bacillus Calmette-Guerin (BCG)
Year2020
CountryUnited States|Korea, Republic of
Company sponsorCG Oncology, Inc.
Other ID(s)CG2003C|Mk3475 Keynote 935
Vector information
Vectoradenovirus
ConstructAd5-E2F-E1A-GMCSF
Vector typea first generation, replication-defective adenovirus serotype 5 (Ad5) vector
Transgene/Inserted genethe human GM-CSF cytokine gene
Regulatory elementE2F-1 promoter
Viral genome modificationAd5 adenovirus was engineered with the human E2F-1 promoter driving the E1A gene, and the human GM-CSF gene inserted.
Additional featureGM-CSF

Clinical Result

Cohort 1
Administration route intravesical injection|intravenous infusion
Dosage CG0070, weekly x 6 on Day 1 to Week 6, Beginning at Week 24, patients will receive weekly x 3 treatments every 3 months through Week 48 then every 24 weeks thereafte|Pembrolizumab, on Day 1 and continue every 3 weeks for up to 2 years
Pts 35
Age Adult, Older_Adult
References PMID: 38844794

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