Basic Information

Gene symbol CSF2 Synonyms CSF, GMCSF Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description colony stimulating factor 2

Gene symbol E2F1 Synonyms E2F-1, RBAP1, RBBP3, RBP3 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description E2F transcription factor 1

GTO ID GTC3967
Trial ID NCT04610671
Disease Bladder Cancer
Altered gene E2F1|CSF2
Therapeutic/Target gene Therapeutic gene
TherapyDNA oncolytic virus
Treatment CG0070|Cretostimogene Grenadenorepvec
Co-treatment Nivolumab
PhasePhase1
Recruitment statusActive, Not Recruiting
TitleA Phase 1 Study of CG0070 Combined With Nivolumab in Cisplatin Ineligible Patients With Muscle Invasive Bladder Cancer (MIBC)
Year2020
CountryUnited States
Company sponsorH. Lee Moffitt Cancer Center and Research Institute
Other ID(s)MCC-20575
Vector information
Vectoradenovirus
ConstructAd5-E2F-E1A-GMCSF
Vector typea first generation, replication-defective adenovirus serotype 5 (Ad5) vector
Transgene/Inserted genethe human GM-CSF cytokine gene
Regulatory elementE2F-1 promoter
Viral genome modificationAd5 adenovirus was engineered with the human E2F-1 promoter driving the E1A gene, and the human GM-CSF gene inserted.
Additional featureGM-CSF

Clinical Result

Cohort 1
Administration route intravesical injection|intravenous infusion
Dosage CG0070, 1E12 vp, 6 instillations|nivolumab, 480 mg, Q4W for 2 doses (week 2 and 6)
Pts 21
Age Adult, Older_Adult

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