Basic Information

Gene symbol CSF2 Synonyms CSF, GMCSF Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description colony stimulating factor 2

Gene symbol E2F1 Synonyms E2F-1, RBAP1, RBBP3, RBP3 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description E2F transcription factor 1

GTO ID GTC3965
Trial ID NCT02365818
Disease Bladder Cancer
Altered gene E2F1|CSF2
Therapeutic/Target gene Therapeutic gene
TherapyDNA oncolytic virus
Treatment CG0070|Cretostimogene Grenadenorepvec
PhasePhase2
Recruitment statusCompleted
TitleAn Open Label, Single Arm, Phase II, Multicenter Study of the Safety and Efficacy of CG0070 Oncolytic Vector Regimen in Patients With Non-Muscle Invasive Bladder Carcinoma Who Have Failed BCG (Bacillus Calmette-Guerin) Therapy and Refused Cystectomy
Year2015
CountryUnited States
Company sponsorCG Oncology, Inc.
Other ID(s)BOND 2 version 3.8
Vector information
Vectoradenovirus
ConstructAd5-E2F-E1A-GMCSF
Vector typea first generation, replication-defective adenovirus serotype 5 (Ad5) vector
Transgene/Inserted genethe human GM-CSF cytokine gene
Regulatory elementE2F-1 promoter
Viral genome modificationAd5 adenovirus was engineered with the human E2F-1 promoter driving the E1A gene, and the human GM-CSF gene inserted.
Additional featureGM-CSF

Clinical Result

Cohort 1
Administration route intravesical injection
Dosage CG0070, a dose of 1E12 vp, weekly for six weeks
Pts 66
Age Adult, Older_Adult
References PMID: 28755959

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