Basic Information

Gene symbol CD276 Synonyms 4Ig-B7-H3, B7-H3, B7H3, B7RP-2 Type of gene protein-coding
Description CD276 molecule

GTO ID GTC3943
Trial ID NCT06500819
Disease Neuroblastoma | Sarcoma | Osteosarcoma
Altered gene CD276
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment B7-H3 CAR-T cells
PhasePhase1
Recruitment statusNot Recruiting
TitlePhase I Clinical Trial of Autologous B7-H3 Chimeric Antigen Receptor T Cells (B7-H3CART) in Children and Young Adults With Relapsed or Refractory Solid Tumor Expressing B7-H3 Target
Year2024
CountryUnited States
Company sponsorStanford University
Other ID(s)IRB-74070

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 0.3E6 cells/kg, 1E6 cells/kg, 3E6 cells/kg, 9E6 cells/kg
Donor type autologous
Pts 41
Age Child, Adult
Lymph depletion Yes

Relationship Graph

Overview of Knowledge Graph