Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

Gene symbol MS4A1 Synonyms B1, Bp35, CD20, CVID5, FMC7, LEU-16, S7 Type of gene protein-coding
Description membrane spanning 4-domains A1

GTO ID GTC3905
Trial ID NCT06462144
Disease Systemic Lupus Erythematosus | Vasculitis | Idiopathic Inflammatory Myopathy
Altered gene CD19|CD20
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment IMPT-514
PhaseEarly_Phase1
Recruitment statusNot Recruiting
TitleAn Exploartory Trial of IMPT-514, An Autologous Anti-CD19/20 CAR T Therapy in Participants With Active, Refractory Systemic Lupus Erythematosus, Anca-associated Vasculitis, and Idiopathic Inflammatory Myopathy
Year2024
CountryChina
Company sponsorThe Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Other ID(s)RD17-01

Clinical Result

Cohort 1
Administration route intravenous infusion
Donor type autologous
Pts 36
Age Adult, Older_Adult
Lymph depletion Yes

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