Basic Information

Gene symbol VEGFA Synonyms L-VEGF, MVCD1, VEGF, VPF Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description vascular endothelial growth factor A

GTO ID GTC3902
Trial ID NCT06458595
Disease Age-Related Macular Degeneration
Altered gene VEGFA
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment KH658
PhasePhase1|Phase2
Recruitment statusNot Recruiting
TitleA Phase I/II Study to Evaluate the Tolerability, Safety and Efficacy of KH658 Gene Therapy in Subjects With Neovascular Age-related Macular Degeneration (nAMD).
Year2024
CountryChina
Company sponsorChengdu Origen Biotechnology Co., Ltd.
Other ID(s)KH658-40101
Vector information
Vectoradeno-associated virus
ConstructAAV-anti-VEGF protein
Vector typeadeno-associated virus (AAV) vector
Transgene/Inserted geneencoding a human VEGF receptor fusion protein

Clinical Result

Cohort 1
Administration route ophthalmic injection
Pts 44
Age Adult, Older_Adult

Relationship Graph

Overview of Knowledge Graph