Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC3860
Trial ID NCT06378190
Disease B-Cell Lymphoma
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment TranspoCART19 cells
PhasePhase1|Phase2
Recruitment statusRecruiting
TitleMulticentre Phase I/IIa Study of Infusion of Autologous Peripheral Blood T Lymphocytes Expanded and Genetically Modified Using Sleeping Beauty Family Transposons to Express a Chimeric Antigenic Receptor With Anti-CD19 Specificity Conjugated to the 4-1BB Co-stimulatory Region and CD3z and huEGFRt Signal Transmission (TranspoCART19) in Patients With Relapsed or Refractory B-cell Lymphoma
Year2024
CountrySpain
Company sponsorInstituto de Investigación Biomédica de Salamanca
Other ID(s)TranspoCART19|2022-001040-23
Vector information
VectorSleeping Beauty system

Clinical Result

Cohort 1
Administration route infusion
Dosage 1E6 cells/kg, 3E6 cells/kg, 5E6 cells/kg
Donor type autologous
Pts 27
Age Adult, Older_Adult

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