Basic Information

Gene symbol VEGFA Synonyms L-VEGF, MVCD1, VEGF, VPF Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description vascular endothelial growth factor A

GTO ID GTC3741
Trial ID NCT06237777
Disease Diabetic Macular Edema
Altered gene VEGFA
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment SKG0106
PhasePhase1
Recruitment statusRecruiting
TitleAn Open, Dose-escalation Clinical Study Evaluating the Safety, Tolerability and Initial Efficacy of SKG0106 Intravitreal Injection in Diabetic Macular Edema (DME) Patients in China
Year2024
CountryChina
Company sponsorWang Min
Other ID(s)SKG0106-002
Vector information
Vectoradeno-associated virus
ConstructrAAV-anti-VEGF protein
Vector typerecombinant adeno-associated virus (rAAV) vector
Transgene/Inserted genea novel transgene genome that encodes an anti-vascular endothelial growth factor (VEGF) protein

Clinical Result

Cohort 1
Administration route intravitreal injection
Pts 18
Age Adult, Older_Adult
References : SKG0106, an AAV vector delivered intravitreally, for effective, safe and durable treatment of nAMD

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