Basic Information

Gene symbol ERBB2 Synonyms CD340, HER-2, HER-2/neu, HER2, MLN 19, MLN-19, NEU, NGL, TKR1, VSCN2, c-ERB-2, c-ERB2, p185(erbB2) Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description erb-b2 receptor tyrosine kinase 2

GTO ID GTC3734
Trial ID NCT06224738
Disease Gastric Cancer
Altered gene HER2
Therapeutic/Target gene Target gene
TherapyCAR-M cell
Treatment HER2 CAR-M cell
PhaseEarly_Phase1
Recruitment statusNot Recruiting
TitleHuman HER2-targeted Chimeric Antigen Receptor Macrophages Therapy for HER2-positive Advanced Gastric Cancer With Peritoneal Metastases: an Exploratory Clinical Trial
Year2024
CountryChina
Company sponsorFirst People's Hospital of Hangzhou
Other ID(s)ITT-20231107-0257-02
Vector information
Vectoradenovirus
Constructhuman HER2-targeted CAR-M cells
Vector typeadenoviral vector
Transgene/Inserted geneCAR molecules containing single-chain antibodies, which specifically bind to the human HER2 antigen

Clinical Result

Cohort 1
Administration route intraperitoneal injection
Dosage 3E8 cells, 5E8 cells, 1E9 cells
Donor type autologous
Pts 9
Age Adult, Older_Adult

Relationship Graph

Overview of Knowledge Graph