Basic Information

Gene symbol VEGFA Synonyms L-VEGF, MVCD1, VEGF, VPF Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description vascular endothelial growth factor A

GTO ID GTC3713
Trial ID NCT06198413
Disease Age-Related Macular Degeneration
Altered gene VEGFA
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment LX102
PhasePhase1
Recruitment statusRecruiting
TitleA Dose-Escalation Study of LX102 Gene Therapy for Neovascular Age-Related Macular Degeneration (nAMD)
Year2023
CountryChina
Company sponsorInnostellar Biotherapeutics Co.,Ltd
Other ID(s)INNOSTELLAR-LX102A01-1
Vector information
Vectoradeno-associated virus
ConstructAAV-coVEGF-trap
Vector typeadeno-associated virus (AAV) vector
Transgene/Inserted genecodon-optimized sequence encoding VEGF-trap

Clinical Result

Cohort 1
Administration route subretinal injection
Age Adult, Older_Adult

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