Basic Information

Gene symbol TNFRSF13C Synonyms BAFF-R, BAFFR, BROMIX, CD268, CVID4, prolixin Type of gene protein-coding
Description TNF receptor superfamily member 13C

GTO ID GTC3702
Trial ID NCT06191887
Disease B-Cell Non-Hodgkin's Lymphoma | Chronic Lymphocytic Leukemia | Diffuse Large B-Cell Lymphoma | Follicular Lymphoma | Mantle Cell Lymphoma | Marginal Zone Lymphoma | Small Lymphocytic Lymphoma
Altered gene BAFFR
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment MC10029
Co-treatment Bendamustine
PhasePhase1
Recruitment statusRecruiting
TitlePhase 1a/1b Dose Escalation and Cohort Expansion Study of the Safety and Efficacy of B-Cell Activating Factor Receptor (BAFFR)-Based Chimeric Antigen Receptor T-Cells (MC10029) in Subjects With Relapsed or Refractory BAFFR-Expressing B-Cell Hematologic Malignancies
Year2024
CountryUnited States
Company sponsorMayo Clinic
Other ID(s)MC230807|NCI-2023-10077|23-004166|MC230807

Clinical Result

Cohort 1
Administration route intravenous infusion
Donor type autologous
Pts 27
Age Adult, Older_Adult
Lymph depletion Yes

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