Basic Information

Gene symbol EPHA2 Synonyms ARCC2, CTPA, CTPP1, CTRCT6, ECK Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description EPH receptor A2

Gene symbol IL13RA2 Synonyms CD213A2, CT19, IL-13R, IL13BP Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description interleukin 13 receptor subunit alpha 2

GTO ID GTC3699
Trial ID NCT06186401
Disease Glioblastoma
Altered gene EPHA2|IL13RA2
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment E-SYNC T cells
PhasePhase1
Recruitment statusRecruiting
TitlePhase 1 Study of Autologous Anti-EGFRvIII synNotch Receptor Induced Anti-EphA2/IL-13R alpha2 CAR (E-SYNC) T Cells in Adult Participants With EGFRvIII+ Glioblastoma
Year2024
CountryUnited States
Company sponsorHideho Okada, MD, PhD
Other ID(s)23704|5U19CA264338-03

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 5E7 cells, 1.5E8 cells
Donor type autologous
Pts 20
Age Adult, Older_Adult
Lymph depletion Yes

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