Basic Information

Gene symbol TERT Synonyms CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description telomerase reverse transcriptase

GTO ID GTC3639
Trial ID NCT06102525
Disease Glioblastoma
Altered gene TERT
Therapeutic/Target gene Target gene|Therapeutic gene
TherapyRibozyme
Treatment RZ-001
Co-treatment VGCV
PhasePhase1|Phase2
Recruitment statusNot Recruiting
TitleA Phase 1/2a, Open-label, Multicenter, Dose Escalation and Dose Expansion Study Evaluating the Safety, Tolerability, and Efficacy of RZ-001 in Combination With Valganciclovir in Subjects With Glioblastoma
Year2023
CountryUnited States
Company sponsorRibozyome
Other ID(s)RZ-001-201
Vector information
Vectoradenovirus
ConstructAd-ECRT-122T
Vector typerecombinant adenovirus harboring the modified ribozyme
Transgene/Inserted genehuman TERT mRNA; HSVtk-encoding sequence

Clinical Result

Cohort1: RZ-001_Dose 1
Administration route intratumoral injection|oral
Dosage RZ-001, Dose 1
Age Adult, Older_Adult
References : Rznomics Inc. Secures Orphan Drug Designation from FDA for RZ-001 in Hepatocellular Carcinoma
Cohort2: RZ-001_Dose 2
Administration route intratumoral injection|oral
Dosage RZ-001, Dose 2
Age Adult, Older_Adult
References : Rznomics Inc. Secures Orphan Drug Designation from FDA for RZ-001 in Hepatocellular Carcinoma
Cohort3: RZ-001_Dose 3
Administration route intratumoral injection|oral
Dosage RZ-001, Dose 3
Age Adult, Older_Adult
References : Rznomics Inc. Secures Orphan Drug Designation from FDA for RZ-001 in Hepatocellular Carcinoma
Cohort4: RZ-001_Dose 4
Administration route intratumoral injection|oral
Dosage RZ-001, Dose 4
Age Adult, Older_Adult
References : Rznomics Inc. Secures Orphan Drug Designation from FDA for RZ-001 in Hepatocellular Carcinoma
Cohort5: RZ-001_Dose 5
Administration route intratumoral injection|oral
Dosage RZ-001, Dose 5
Age Adult, Older_Adult
References : Rznomics Inc. Secures Orphan Drug Designation from FDA for RZ-001 in Hepatocellular Carcinoma
Cohort6: RZ-001_Dose 6
Administration route intratumoral injection|oral
Dosage RZ-001, Dose 6
Age Adult, Older_Adult
References : Rznomics Inc. Secures Orphan Drug Designation from FDA for RZ-001 in Hepatocellular Carcinoma

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