Basic Information

Gene symbol TNFRSF17 Synonyms BCM, BCMA, CD269, TNFRSF13A Type of gene protein-coding
Description TNF receptor superfamily member 17

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC3599
Trial ID NCT06056102
Disease Kidney Transplant | Kidney Failure
Altered gene BCMA|CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment BCMA CAR-T cells|CD19 CAR-T cells
Recruitment statusNot Recruiting
TitleCAR-T Cell Therapy for Desensitization in Kidney Transplantation
Year2024
CountryUnited States
Company sponsorNational Institute of Allergy and Infectious Diseases
Other ID(s)DAIT CTOT-46

Clinical Result

Cohort1: dose level 1
Administration route None
Dosage 5E7 cells, 5E7 cells
Donor type Autologous
Pts 2
Age Adult, Older_Adult
Lymph depletion Yes
Cohort2: dose level 2
Administration route None
Dosage 1.5E8 cells, 1.5E8 cells
Donor type Autologous
Pts 3~6
Age Adult, Older_Adult
Cohort3: dose level 3
Administration route None
Dosage 5E8 cells, 5E8 cells
Donor type Autologous
Pts 3~6
Age Adult, Older_Adult

Relationship Graph

Overview of Knowledge Graph