Basic Information

Gene symbol FOLH1 Synonyms FGCP, FOLH, GCP2, GCPII, NAALAD1, PSM, PSMA, mGCP Type of gene protein-coding
Description folate hydrolase 1

GTO ID GTC3592
Trial ID NCT06046040
Disease Prostate Cancer
Altered gene PSMA
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment TmPSMA-02 CAR-T cells
PhasePhase1
Recruitment statusRecruiting
TitlePhase I, Open-Label Study of Dually Armored Chimeric Antigen Receptor (CAR) T Cells (TmPSMA-02) in Patients With Metastatic Castrate-Resistant Prostate Cancer (mCRPC)
Year2024
CountryUnited States
Company sponsorUniversity of Pennsylvania
Other ID(s)UPCC 11823
Vector information
Vectorlentivirus

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 1E7 cells, 5E7 cells, 1E8 cells, 3E8 cells
Donor type autologous
Pts 18
Age Adult, Older_Adult
Lymph depletion Yes

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