| Gene symbol | KRAS | Synonyms | C-K-RAS, C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, K-Ras, K-Ras 2, KI-RAS, KRAS1, KRAS2, NS, NS3, OES, RALD, RASK2, c-Ki-ras, c-Ki-ras2 | Type of gene | protein-coding |
| Chromosome | 12 | Map location | 12p12.1 | dbXrefs | |
| Gene perturbation-related omics dataset | PerturbAtlas | PertOrg | ||||
| Description | KRAS proto-oncogene, GTPase | ||||
| GTO ID | GTC3588 |
| Trial ID | NCT06043713 |
| Disease | Colorectal Adenocarcinoma | Lung Non-Small Cell Carcinoma | Pancreatic Adenocarcinoma |
| Altered gene | KRAS |
| Therapeutic/Target gene | Target gene |
| Therapy | TCR-T cell |
| Treatment | KRAS TCR-T cells |
| Co-treatment | Bendamustine |
| HLA | HLA-A*11:01 |
| Phase | Phase1 |
| Recruitment status | Recruiting |
| Title | Phase I Study of Autologous CD8+ and CD4+ Transgenic T Cells Expressing High Affinity KRASG12V Mutation-Specific T Cell Receptors in Participants With Metastatic Pancreatic, Colorectal and Non-Small Cell Lung Cancers With KRAS G12V Mutations |
| Year | 2023 |
| Country | United States |
| Company sponsor | Fred Hutchinson Cancer Center |
| Other ID(s) | RG1123135|NCI-2023-06287|20048 |
| Cohort 1 | |||||||||||
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