Basic Information

Gene symbol VEGFA Synonyms L-VEGF, MVCD1, VEGF, VPF Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description vascular endothelial growth factor A

GTO ID GTC3576
Trial ID NCT06022744
Disease Age-Related Macular Degeneration
Altered gene VEGFA
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment LX109
Recruitment statusNot Recruiting
TitleAn Exploratory Clinical Trial Evaluating LX109 Gene Therapy in Patients With Neovascular Age-related Macular Degeneration (nAMD)
Year2023
CountryChina
Company sponsorShanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Other ID(s)SHGH-LX109
Vector information
Vectoradeno-associated virus
Vector typeadeno-associated virus (AAV) vector
Transgene/Inserted geneVEGFA

Clinical Result

Cohort1: dose level 1
Administration route intravitreal injection
Dosage 7E9 vg/eye, 0.05ml
Age Adult, Older_Adult
Cohort2: dose level 2
Administration route intravitreal injection
Dosage 3.5E10 vg/eye, 0.05ml
Age Adult, Older_Adult

Relationship Graph

Overview of Knowledge Graph