Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

Gene symbol IL18 Synonyms IGIF, IL-18, IL-1g, IL1F4 Type of gene protein-coding
Gene perturbation-related omics dataset PertOrg
Description interleukin 18

GTO ID GTC3547
Trial ID NCT05989204
Disease Non-Hodgkin's Lymphoma
Altered gene CD19|IL-18
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment TmCD19-IL18
PhasePhase1
Recruitment statusRecruiting
TitlePhase I Trial of TmCD19-IL18 CAR T Cells in Patients With Relapsed or Refractory CD19+ Cancers
Year2023
CountryUnited States
Company sponsorUniversity of Pennsylvania
Other ID(s)UPCC 12423

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 7E6 cells, 3E6 cells, 3E7 cells, 7E7 cells
Donor type autologous
Pts 24
Age Adult, Older_Adult

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