Basic Information

Gene symbol VEGFA Synonyms L-VEGF, MVCD1, VEGF, VPF Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description vascular endothelial growth factor A

GTO ID GTC3543
Trial ID NCT05986864
Disease Age-Related Macular Degeneration
Altered gene VEGFA
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment SKG0106
PhasePhase1|Phase2
Recruitment statusNot Recruiting
TitleA Multicenter, Open-label, Dose Escalation, Phase 1 Clinical Study and Randomized, Double-masked, Controlled, Dose Expansion Phase 2 Clinical Study to Evaluate the Safety, Preliminary Efficacy, Immunogenicity, and Pharmacokinetics of SKG0106 Intraocular Solution in Patients With Neovascular Age-related Macular Degeneration (nAMD)
Year2023
CountryUnited States
Company sponsorSkyline Therapeutics (US) Inc.
Other ID(s)SKG0106-101
Vector information
Vectoradeno-associated virus
ConstructrAAV-anti-VEGF protein
Vector typerecombinant adeno-associated virus (rAAV) vector
Transgene/Inserted genea novel transgene genome that encodes an anti-vascular endothelial growth factor (VEGF) protein

Clinical Result

Cohort 1
Administration route intraocular injection
Age Adult, Older_Adult
References : SKG0106, an AAV vector delivered intravitreally, for effective, safe and durable treatment of nAMD

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