Basic Information

Gene symbol TNFRSF17 Synonyms BCM, BCMA, CD269, TNFRSF13A Type of gene protein-coding
Description TNF receptor superfamily member 17

Gene symbol TGFB1 Synonyms CED, DPD1, IBDIMDE, LAP, TGF-beta1, TGFB, TGFbeta Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description transforming growth factor beta 1

GTO ID GTC3531
Trial ID NCT05976555
Disease Multiple Myeloma
Altered gene BCMA|TGFB
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment BCMA-TGFβ CAR-T cells
PhasePhase1
Recruitment statusNot Recruiting
TitlePhase I Study of BCMA-TGF-BETA Insensitive Armored CAR T Cells in Patients With Relapsed and/or Refractory Multiple Myeloma
Year2024
CountryUnited States
Company sponsorMedical College of Wisconsin
Other ID(s)IIT-DHAKAL-TGF-BETA-BCMA

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 0.50E6 cells/kg, 0.75E6 cells/kg, 1E6 cells/kg, 2.5E6 cells/kg
Pts 30
Age Adult, Older_Adult

Relationship Graph

Overview of Knowledge Graph