Gene symbol | TNFRSF17 | Synonyms | BCM, BCMA, CD269, TNFRSF13A | Type of gene | protein-coding |
Chromosome | 16 | Map location | 16p13.13 | dbXrefs | |
Description | TNF receptor superfamily member 17 |
Gene symbol | TGFB1 | Synonyms | CED, DPD1, IBDIMDE, LAP, TGF-beta1, TGFB, TGFbeta | Type of gene | protein-coding |
Chromosome | 19 | Map location | 19q13.2 | dbXrefs | |
Gene perturbation-related omics dataset | PerturbAtlas | PertOrg | ||||
Description | transforming growth factor beta 1 |
GTO ID | GTC3531 |
Trial ID | NCT05976555 |
Disease | Multiple Myeloma |
Altered gene | BCMA|TGFB |
Therapeutic/Target gene | Target gene |
Therapy | CAR-T cell |
Treatment | BCMA-TGFβ CAR-T cells |
Phase | Phase1 |
Recruitment status | Not Recruiting |
Title | Phase I Study of BCMA-TGF-BETA Insensitive Armored CAR T Cells in Patients With Relapsed and/or Refractory Multiple Myeloma |
Year | 2024 |
Country | United States |
Company sponsor | Medical College of Wisconsin |
Other ID(s) | IIT-DHAKAL-TGF-BETA-BCMA |
Cohort 1 | |||||||||
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