Basic Information

Gene symbol CLDN18 Synonyms SFTA5, SFTPJ Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description claudin 18

GTO ID GTC3511
Trial ID NCT05946226
Disease Digestive System Tumor
Altered gene CLDN18
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment IMC002
PhasePhase1
Recruitment statusRecruiting
TitleA Phase I, Open-label, Multi-center, Dose-escalation Study to Evaluate the Safety, Feasibility, and Preliminary Efficacy of IMC002 in Patients With Claudin18.2-positive Advanced Digestive System Tumors
Year2023
CountryChina
Company sponsorSuzhou Immunofoco Biotechnology Co., Ltd
Other ID(s)IMC002-RT01

Clinical Result

Cohort 1
Administration route infusion
Dosage 1.0E8 cells, 2.5E8 cells, 5.0E8 cells
Donor type autologous
Pts 18
Age Adult, Older_Adult
Lymph depletion Yes

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