Basic Information

Gene symbol CTAG1B Synonyms CTAG, ESO1, CT6.1, CTAG1, LAGE-2, LAGE2B, NY-ESO-1 Type of gene protein-coding
Description cancer/testis antigen 1B

GTO ID GTC3508
Trial ID NCT05943990
Disease Myxoid Liposarcoma | Synovial Sarcoma
Altered gene NY-ESO-1
Therapeutic/Target gene Target gene
TherapyTCR-T cell
Treatment GSK3901961
HLAHLA-A*02:01|HLA-A*02:05|HLA-A*02:06
PhasePhase1
Recruitment statusTerminated
TitleAssessment of Safety and Recommended Phase 2 Dose of Autologous T Cells Engineered With an Affinity-enhanced TCR Targeting NY ESO 1 and LAGE 1a, and Co-expressing the dnTGF-βRII (GSK3845097) in Participants With NY ESO 1 and/or LAGE 1a Positive Previously Treated Advanced (Metastatic or Unresectable) Synovial Sarcoma and Myxoid/Round Cell Liposarcoma
Year2023
CountryUnited States
Company sponsorGlaxoSmithKline
Other ID(s)209012 Substudy 2|2019-004446-14

Clinical Result

Cohort 1
Administration route infusion
Donor type autologous
Age Adult, Older_Adult
Lymph depletion Yes

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