Basic Information

Gene symbol VEGFC Synonyms Flt4-L, LMPH1D, LMPHM4, VRP Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description vascular endothelial growth factor C

GTO ID GTC3498
Trial ID NCT05930561
Disease Diabetic Macular Edema
Altered gene VEGFC
Therapeutic/Target gene Target gene|Therapeutic gene
TherapymiRNA|mRNA
Treatment 4D-150
PhasePhase2
Recruitment statusRecruiting
TitleA Phase 2 Randomized, Active-Controlled, Double-masked Trial of Intravitreal 4D-150 Gene Therapy in Adults With Diabetic Macular Edema (SPECTRA)
Year2023
CountryUnited States|Puerto Rico
Company sponsor4D Molecular Therapeutics
Other ID(s)4D-150-C002
Vector information
Vectoradeno-associated virus
Vector typeadeno-associated virus (AAV) capsid variant (4D-R100)
Transgene/Inserted geneVEGF-C miRNA; codon-optimized sequence encoding aflibercept

Clinical Result

Cohort1: 4D-150
Administration route intravitreal injection
Dosage 4D-150, single dose, Day 1
Age Adult, Older_Adult
References 38927656|DOI: 10.1101/2021.06.24.449775
Cohort2: Aflibercept
Administration route intravitreal injection
Age Adult, Older_Adult
References 38927656|DOI: 10.1101/2021.06.24.449775

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