Basic Information


GTO ID GTC3489
Trial ID NCT05921162
Disease Retinitis Pigmentosa | Retinal Degeneration | Retinal Disease
Altered gene MCO
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment vMCO-I|AAV2-MCO
Recruitment statusRecruiting
TitleA Long-Term Follow-Up Study in Subjects Who Received an Adeno-Associated Viral Vector Serotype 2 Containing the Multi-Characteristic Opsin Gene (vMCO-I) Administered Via Intravitreal Injection
Year2023
CountryIndia
Company sponsorNanoscope Therapeutics Inc.
Other ID(s)NTXMCO-005
Vector information
Vectoradeno-associated virus
ConstructAAV2-MCO
Vector typeadeno-associated virus serotype 2 (AAV2) vector
Transgene/Inserted genemulti-characteristic opsin (MCO) gene

Clinical Result

Cohort1: dose level 1
Administration route intravitreal injection
Dosage 1.2E11 gc/eye
Age Adult, Older_Adult
References PMID: 37132114
Cohort2: dose level 2
Administration route intravitreal injection
Dosage 0.6E11 gc/eye
Age Adult, Older_Adult
References PMID: 37132114

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