Basic Information

Gene symbol ANGPT2 Synonyms AGPT2, ANG2, LMPHM10 Type of gene protein-coding
Gene perturbation-related omics dataset PertOrg
Description angiopoietin 2

Gene symbol VEGFA Synonyms L-VEGF, MVCD1, VEGF, VPF Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description vascular endothelial growth factor A

GTO ID GTC3478
Trial ID NCT05903794
Disease Age-Related Macular Degeneration
Altered gene VEGFA|ANGPT2
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment EXG102-031
PhasePhase1
Recruitment statusRecruiting
TitleAn Open-label, Dose-escalation Study to Evaluate the Safety and Tolerability of Gene Therapy With EXG102-031 in Participants With Neovascular Age-related Macular Degeneration.
Year2023
CountryUnited States
Company sponsorExegenesis Bio
Other ID(s)EXG102-031 (211)
Vector information
Vectoradeno-associated virus
ConstructrAAV-ABD-VEGFR
Vector typerecombinant adeno-associated virus (rAAV) vector
Transgene/Inserted genean angiopoietin domain and VEGF receptor (ABD-VEGFR) fusion protein

Clinical Result

Cohort 1
Administration route subretinal injection
Age Adult, Older_Adult
References : Efficacy Evaluation of EXG102-031, A Novel AAV-based Gene Therapy for Neovascular AMD in a Mouse Model of VEGF-A-induced Exudative Retinal Detachment vascular leakage Mouse Model

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