Basic Information

Gene symbol STAT3 Synonyms ADMIO, ADMIO1, APRF, HIES Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description signal transducer and activator of transcription 3

GTO ID GTC3404
Trial ID NCT05814666
Disease Head and Neck Squamous Cell Carcinoma
Altered gene STAT3
Therapeutic/Target gene Target gene
TherapyASO
Treatment ISIS-STAT3rx|AZD9150|ISIS 481464|IONIS-STAT3-2.5Rx
Co-treatment pembrolizumab
PhasePhase2
Recruitment statusRecruiting
TitleAn Open-Label, Phase II, Randomized, Controlled Study of Danvatirsen Plus Pembrolizumab Compared to Pembrolizumab Alone in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (HNSCC)
Year2023
CountryUnited States|Korea, Republic of
Company sponsorFlamingo Therapeutics NV
Other ID(s)FLM-6774-201
Vector information
VectorNo vector was used

Clinical Result

Cohort1: Danvatirsen_pembrolizumab
Administration route intravenous injection
Dosage Danvatirsen, Week 1, on Days 1, 3, and 5, Week 2 and subsequent weeks, weekly|Pembrolizumab, every 3 weeks after the Danvatirsen dose.
Age Adult, Older_Adult
Cohort2: pembrolizumab
Administration route intravenous injection
Dosage pembrolizumab, every 3 weeks
Age Adult, Older_Adult

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