Basic Information

Gene symbol RHO Synonyms CSNBAD1, OPN2, RP4 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description rhodopsin

GTO ID GTC3398
Trial ID NCT05805007
Disease Retinitis Pigmentosa
Altered gene RHO
Therapeutic/Target gene Target gene
TherapyGene editing
Treatment ZVS203e
PhaseEarly_Phase1
Recruitment statusRecruiting
TitleA Single-arm, Open-label Exploratory Clinical Study to Assess the Preliminary Safety of the Gene Editing Drug ZVS203e for the Management of Retinitis Pigmentosa Caused by Mutations in the RHO Gene
Year2023
CountryChina
Company sponsorPeking University Third Hospital
Other ID(s)ZYB-2022-001
Vector information
Vectoradeno-associated virus
Vector typerecombinant adeno-associated virus (rAAV) vector
Transgene/Inserted geneCRISPR/Cas9 editing system

Clinical Result

Cohort 1
Administration route subretinal injection
Pts 9
Age Adult, Older_Adult

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