| Gene symbol | CD276 | Synonyms | 4Ig-B7-H3, B7-H3, B7H3, B7RP-2 | Type of gene | protein-coding |
| Chromosome | 15 | Map location | 15q24.1 | dbXrefs | |
| Description | CD276 molecule | ||||
| Gene symbol | EGFR | Synonyms | ERBB, ERBB1, ERRP, HER1, NISBD2, PIG61, mENA | Type of gene | protein-coding |
| Chromosome | 7 | Map location | 7p11.2 | dbXrefs | |
| Gene perturbation-related omics dataset | PerturbAtlas | PertOrg | ||||
| Description | epidermal growth factor receptor | ||||
| Gene symbol | ERBB2 | Synonyms | CD340, HER-2, HER-2/neu, HER2, MLN 19, MLN-19, NEU, NGL, TKR1, VSCN2, c-ERB-2, c-ERB2, p185(erbB2) | Type of gene | protein-coding |
| Chromosome | 17 | Map location | 17q12 | dbXrefs | |
| Gene perturbation-related omics dataset | PerturbAtlas | PertOrg | ||||
| Description | erb-b2 receptor tyrosine kinase 2 | ||||
| Gene symbol | IL13 | Synonyms | IL-13, P600 | Type of gene | protein-coding |
| Chromosome | 5 | Map location | 5q31.1 | dbXrefs | |
| Gene perturbation-related omics dataset | PerturbAtlas | PertOrg | ||||
| Description | interleukin 13 | ||||
| GTO ID | GTC3368 |
| Trial ID | NCT05768880 |
| Disease | Diffuse Intrinsic Pontine Glioma | Primary Malignant Central Nervous System Neoplasm |
| Altered gene | CD276|EGFR|HER2|IL13 |
| Therapeutic/Target gene | Target gene |
| Therapy | CAR-T cell |
| Treatment | SC-CAR4BRAIN |
| Phase | Phase1 |
| Recruitment status | Recruiting |
| Title | Study of B7-H3, EGFR806, HER2, And IL13-Zetakine (Quad) CAR T Cell Locoregional Immunotherapy For Pediatric Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, And Recurrent Or Refractory Central Nervous System Tumors |
| Year | 2023 |
| Country | United States |
| Company sponsor | Seattle Children's Hospital |
| Other ID(s) | BrainChild-04 |
| Cohort 1 | |||||||||
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