Basic Information

Gene symbol GPRC5D Synonyms None Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description G protein-coupled receptor class C group 5 member D

GTO ID GTC3362
Trial ID NCT05759793
Disease Multiple Myeloma | Plasma Cell Leukemia
Altered gene GPRC5D
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment GPRC5D CAR-T cells
Generation2nd
PhasePhase1
Recruitment statusNot Recruiting
TitleA Study of CAR-GPRC5D in Patients With Relapsed/Refractory Multiple Myeloma or Plasma Cell Leukemia
Year2023
CountryChina
Company sponsorNanjing IASO Biotherapeutics Co., Ltd
Other ID(s)RD138CI002
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ

Clinical Result

Cohort 1
Administration route None
Dosage 0.5E6 cells/kg, 1E6 cells/kg, 2E6 cells/kg
Pts 12
Age Adult, Older_Adult
Lymph depletion Yes

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