Basic Information

Gene symbol LGR5 Synonyms FEX, GPR49, GPR67, GRP49, HG38 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description leucine rich repeat containing G protein-coupled receptor 5

GTO ID GTC3361
Trial ID NCT05759728
Disease Colorectal Cancer
Altered gene LGR5
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CNA3103
PhasePhase1|Phase2
Recruitment statusNot Recruiting
TitleA Study of CNA3103 (LGR5-targeted, Autologous CAR-T Cells) Administered to Subjects With Metastatic Colorectal Cancer
Year2023
CountryAustralia
Company sponsorCarina Biotech Pty Ltd
Other ID(s)CNA3103-001

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 5E7 cells, 1.5E8 cells, 4.5E8 cells, 1.5E9 cells, 2.5E7 cells
Donor type Autologous
Pts 44
Age Adult, Older_Adult
Lymph depletion Yes

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