Basic Information

Gene symbol NXNL1 Synonyms RDCVF, TXNL6 Type of gene protein-coding
Description nucleoredoxin like 1

GTO ID GTC3354
Trial ID NCT05748873
Disease Retinitis Pigmentosa
Altered gene NXNL1
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment SPVN06
PhasePhase1|Phase2
Recruitment statusRecruiting
TitleA Phase I/II Study to Assess the Safety and Tolerability of a Single Subretinal Administration of SPVN06 Gene Therapy in Subjects With Rod-Cone Dystrophy (RCD) Due to a Mutation in the RHO, PDE6A, or PDE6B Gene
Year2023
CountryFrance|United States
Company sponsorSparingVision
Other ID(s)SPVN06-CLIN-01
Vector information
Vectoradeno-associated virus
ConstructAAV-RdCVF-RdCVFL
Vector typeadeno-associated virus (AAV) vector
Transgene/Inserted genetrophic factor Rod-derived Cone Viability Factor (RdCVF) cDNA and thioredoxin enzyme RdCVF-Long (RdCVFL) cDNA, both isoforms of the NXNL1 gene

Clinical Result

Cohort 1
Administration route subretinal injection
Age Adult, Older_Adult
References : SPVN06, a novel mutation-independent AAV-based gene therapy, dramatically reduces vision loss in the rd10 mouse model of rod-cone dystrophy

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