Basic Information

Gene symbol ADGRE2 Synonyms CD312, CD97, EMR2, VBU Type of gene protein-coding
Description adhesion G protein-coupled receptor E2

Gene symbol CLEC12A Synonyms CD371, CLL-1, CLL1, DCAL-2, MICL Type of gene protein-coding
Description C-type lectin domain family 12 member A

GTO ID GTC3353
Trial ID NCT05748197
Disease Acute Myeloid Leukemia
Altered gene ADGRE2|CLEC12A
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment ADCLEC.syn1 CAR T cells
PhasePhase1
Recruitment statusRecruiting
TitleA Phase I Study of ADCLEC.syn1 CAR T Cells in Adult Patients With Relapsed or Refractory Acute Myeloid Leukemia
Year2024
CountryUnited States
Company sponsorMemorial Sloan Kettering Cancer Center
Other ID(s)23-002

Clinical Result

Cohort 1
Administration route infusion
Dosage 1.0E7 cells, 2.5E7 cells, 7.5E7 cells, 2.25E8 cells, 4.50E8 cells
Pts 40
Age Adult, Older_Adult
Lymph depletion Yes

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